光热治疗
谷胱甘肽
光热效应
双功能
材料科学
氧化还原
辐照
化学
癌症研究
纳米技术
生物物理学
催化作用
生物
生物化学
酶
物理
核物理学
冶金
作者
Xuke Ma,Benjin Chen,Haitao Wu,Qianqian Jin,Wanni Wang,Zhengbao Zha,Haisheng Qian,Yan Ma
摘要
Photothermal-enhanced chemodynamic therapy (CDT) has been attracting increasing attention for effective tumour treatment. Nevertheless, even though Mn-based nanostructures are promising CDT agents, their photothermal conversion capacities are not good enough for an ideal combination therapy. In this work, a bifunctional Bi2-xMnxO3 nanoplatform was developed, with tumour microenvironment (TME)-triggered photothermal therapy (PTT)-enhanced CDT, for a collaborative therapy for tumours. The doping of a small amount of Bi tuned the photothermal and CDT performance of Bi2-xMnxO3, thus promoting the photothermal conversion ability as well as accelerating the ˙OH generation. The existence of reductive Mn4+ could disrupt the internal tumour redox balance by enhancing glutathione (GSH) consumption to improve the CDT effect. Meanwhile, the mild photothermal effect could accelerate the depletion of GSH and the generation of ˙OH in the tumour region after laser irradiation, thus promoting the CDT effect. This manganese-based nanoplatform provides a good strategy for tumour therapy via TME-mediated PTT-enhanced CDT.
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