夫西地酸
透皮
角质层
Zeta电位
诱捕
体内
化学
色谱法
粒径
材料科学
药理学
纳米技术
医学
外科
金黄色葡萄球菌
细菌
生物
生物技术
物理化学
病理
纳米颗粒
遗传学
作者
Monika Sharma,Garima Malik,Diksha Gulati,Peeyush Kaushik,Sahil Arora
标识
DOI:10.1016/j.matpr.2022.06.260
摘要
Transferosome, being very flexible and deformable nature to cross stratum corneum are selected for enhancing the transdermal delivery of fusidic acid. The present research work comprised formulation of fusidic acid transferosome using modified reverse phase evaporation process and characterised for particle size, zeta potential, entrapment efficiency and in vitro drug release. An optimised formulation of transferosome made by Phosphatidyl choline S100 and Span 80 (F2) showed lowest size of 145.16 nm and high drug entrapment efficiency of 87.47 ± 0.119. 2 %w/v Carbopol based transferosomal gel formulation (N4) of Fusidic acid showed entrapment efficiency 78.22% and Fickian diffusion-based release mechanism with 47% and 94% drug release at 6 h and 24 h respectively. The promising results from the current study can be exploited in future research for in-vivo performance.
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