炎症
癌症
生物
病毒
免疫学
癌症研究
细胞凋亡
信号转导
肿瘤病毒
细胞生物学
遗传学
作者
Scott A. Read,Mark W. Douglas
出处
期刊:Cancer Letters
[Elsevier]
日期:2014-04-01
卷期号:345 (2): 174-181
被引量:64
标识
DOI:10.1016/j.canlet.2013.07.030
摘要
Chronic inflammation as a result of viral infection significantly increases the likelihood of cancer development. A handful of diverse viruses have confirmed roles in cancer development and progression, but the list of suspected oncogenic viruses is continually growing. Viruses induce cancer directly and indirectly, by activating inflammatory signalling pathways and cytokines, stimulating growth of infected cells and inhibiting apoptosis. Although oncogenic viruses induce inflammation by various mechanisms, it is generally mediated by the MAPK, NFκB and STAT3 signalling pathways. This review will explore the unique mechanisms by which different oncogenic viruses induce inflammation to promote cancer initiation and progression.
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