Development of gold nanorod-based localized surface plasmon resonance optical fiber biosensor

A localized surface plasmon resonance (LSPR) based optical fiber biosensor using gold nanorods has been developed. The LSPR optical fiber sensor was fabricated by immobilizing gold nanorods at the distal end of a multimode fiber. The surface of gold nanorods was further functionalized with human IgG to create a biosensor to detect anti-human IgG. The peak shift of the longitudinal plasmon wavelength of gold nanorod was monitored as a function of the refractive index change. The results show that refractive index sensitivity of this sensor is 506 nm/RIU, and the limit of detection for antihuman IgG is 3 nM.