Step‐Economical Synthesis of Tetrahydroquinolines by Asymmetric Relay Catalytic Friedländer Condensation/Transfer Hydrogenation

Angewandte Chemie International EditionVolume 51, Issue 3 p. 771-774 Communication Step-Economical Synthesis of Tetrahydroquinolines by Asymmetric Relay Catalytic Friedländer Condensation/Transfer Hydrogenation† Correction(s) for this article Corrigendum: Step-Economical Synthesis of Tetrahydroquinolines by Asymmetric Relay Catalytic Friedlander Condensation/Transfer Hydrogenation Lei Ren, Tao Lei, Jia-Xi Ye, Liu-Zhu Gong, Volume 53Issue 24Angewandte Chemie International Edition pages: 6027-6027 First Published online: June 5, 2014 Lei Ren, Lei Ren Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China) http://staff.ustc.edu.cn/∼gonglz/index.htmSearch for more papers by this authorTao Lei, Tao Lei Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China) http://staff.ustc.edu.cn/∼gonglz/index.htmSearch for more papers by this authorJia-Xi Ye, Jia-Xi Ye Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China) http://staff.ustc.edu.cn/∼gonglz/index.htmSearch for more papers by this authorProf. Liu-Zhu Gong, Corresponding Author Prof. Liu-Zhu Gong gonglz@ustc.edu.cn Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China) http://staff.ustc.edu.cn/∼gonglz/index.htmHefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China) http://staff.ustc.edu.cn/∼gonglz/index.htmSearch for more papers by this author Lei Ren, Lei Ren Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China) http://staff.ustc.edu.cn/∼gonglz/index.htmSearch for more papers by this authorTao Lei, Tao Lei Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China) http://staff.ustc.edu.cn/∼gonglz/index.htmSearch for more papers by this authorJia-Xi Ye, Jia-Xi Ye Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China) http://staff.ustc.edu.cn/∼gonglz/index.htmSearch for more papers by this authorProf. Liu-Zhu Gong, Corresponding Author Prof. Liu-Zhu Gong gonglz@ustc.edu.cn Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China) http://staff.ustc.edu.cn/∼gonglz/index.htmHefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China) http://staff.ustc.edu.cn/∼gonglz/index.htmSearch for more papers by this author First published: 14 December 2011 https://doi.org/10.1002/anie.201106808Citations: 102 † We are grateful for financial support from NSFC (20732006), the Ministry of Health (2009ZX09501-017), MOST (973 project 2010CB833300), and the Ministry of Education. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Two steps in one reaction: The title relay reaction relies on a combination of an achiral Lewis acid and a chiral Brønsted acid (B*-H in the scheme). This one-pot method provides access to tetrahydroquinoline derivatives with multiple continuous stereogenic centers in high stereoselectivity (>20:1 d.r., 98 % ee). Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_201106808_sm_miscellaneous_information.pdf1.7 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume51, Issue3January 16, 2012Pages 771-774 RelatedInformation