Comparison of human papillomavirus genotype distributions in cervical intraepithelial neoplasia and cervical cancer

We evaluated the genotype distributions of human papillomavirus (HPV) in cervical intraepithelial neoplasia (CIN) and cervical cancer (CC) cases. Cervical exfoliated cells from 490 patients (125, 231, and 134 patients in groups CIN1, CIN2+, and CC, respectively) were tested to determine the HPV genotypes. The positive rates were statistically analyzed to determine the correlations between HPV and disease severity. Average age of subjects in the CIN1, CIN2+, and CC groups was 44.3 ± 10.3, 44.1 ± 11.8, and 52.3 ± 10.9 years, respectively. The average age in group CC was higher than that in groups CIN2 + and CIN1 (P<0.001). The following HPV subtypes were the most common in groups CIN1, CIN2+, and CC, respectively: HPV16, HPV58, HPV18, and HPV33; HPV16, HPV58, HPV52, and HPV33; and HPV16, HPV18, HPV58, and HPV33. Group CIN2+ showed a higher positive rate of HPV16/52 and lower positive rate of HPV51 than group CIN1 (P<0.05). Group CC showed a higher positive rate of HPV16 and lower positive rate of HPV33/52/58 than group CIN2+ (P<0.05). Multiple infection rates of HPV were 28.8%, 36.8%, 16.4% in groups CIN1, CIN2+, and CC, respectively, and that in group CC was lower than in groups CIN2+ and CIN1 (P<0.001). HPV16/18 are the most important predisposition factors for CC and HPV33/52/58 showed weak carcinogenicity but belonged to high-risk subtypes of CC; therefore, attention should be given to HPV16/18 and HPV33/52/58 infection.