微生物群
计算生物学
混淆
DNA测序
人体微生物群
生物
数据科学
生物信息学
医学
计算机科学
DNA
遗传学
病理
作者
Sidney P. Walker,Mark Tangney,Marcus J. Claesson
标识
DOI:10.3389/fonc.2020.00179
摘要
Tumors are hospitable environments to bacteria and several recent studies on cancer patient samples have introduced the concept of an endogenous tumor microbiome. For a variety of reasons, this putative tumor microbiome is particularly challenging to investigate, and a failure to account for the various potential pitfalls will result in erroneous results and claims. Before this potentially extremely medically-significant habitat can be accurately characterized, a clear understanding of all potential confounding factors is required, and a best-practice approach should be developed and adopted. This review summarizes all of the potential issues confounding accurate bacterial DNA sequence analysis of the putative tumor microbiome, and offers solutions based on related research with the hope of assisting in the progression of research in this field.
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