癌症研究
免疫疗法
免疫系统
光动力疗法
体内
癌症免疫疗法
结直肠癌
癌症
细胞毒性T细胞
细胞毒性
医学
免疫学
体外
生物
化学
内科学
有机化学
生物技术
生物化学
作者
Xiaoli Wu,Han Na Yang,Xingmeng Chen,Jiangbo Gao,Yue Duan,Daohe Wei,Jinchao Zhang,Kun Ge,Xing‐Jie Liang,Yuanyu Huang,Sizhou Feng,Rongli Zhang,Xi Chen,Jin Chang
出处
期刊:Biomaterials
[Elsevier]
日期:2021-02-01
卷期号:269: 120654-120654
被引量:59
标识
DOI:10.1016/j.biomaterials.2021.120654
摘要
A variety of therapies have been developed and used for the treatment of colon cancer, however, the high mortality rate remains high and more effective strategies are still in urgent needs. In this study, an immunotherapy approach that is composed of innate immune activator Astragaloside III (As) and the photodynamic therapy (PDT) reagent chlorine e6 (Ce6) ((As + Ce6)@MSNs-PEG), was developed for colon cancer treatment. We showed that (As + Ce6)@MSNs-PEG could effectively activate NK cells and inhibit the proliferation of tumor cells in vitro. It could also effectively reach tumor sites, induce infiltration of immune cells into the tumor, and enhance the cytotoxicity of natural killer cells and CD8+ T cells in vivo. Without obvious side effects, (As + Ce6)@MSNs-PEG treatment significantly inhibited tumor growth and extended the lifespan of tumor-bearing mice. Further results revealed that treatment of (As + Ce6)@MSNs-PEG led to enhanced IFN secretion by immune cells and increased T-box transcription factor (T-bet), which is highly expressed by T cells. Therefore, (As + Ce6)@MSNs-PEG may serve as an effective and safe platform for combinatory use with nano-herb medicine and PDT to provide a new therapy for colon cancer treatment.
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