静载荷
精神分裂症(面向对象编程)
脉络丛
医学
内科学
扁桃形结构
心室
内分泌学
精神病
心理学
中枢神经系统
生理学
精神科
作者
Yuwei Zhou,Junchao Huang,Ping Zhang,Fengmei Fan,Chen Song,Hongzhen Fan,Yimin Chen,Xingguang Luο,Shuping Tan,Zhiren Wang,Wei Feng,Ying Yuan,Fude Yang,Anya Savransky,Meghann Ryan,Eric L. Goldwaser,Joshua Chiappelli,Laura M. Rowland,Peter Kochunov,Yunlong Tan,L. Elliot Hong
标识
DOI:10.1093/schbul/sbz100
摘要
Abstract Although schizophrenia is a brain disorder, increasing evidence suggests that there may be body-wide involvement in this illness. However, direct evidence of brain structures involved in the presumed peripheral-central interaction in schizophrenia is still unclear. Seventy-nine previously treatment-naïve first-episode schizophrenia patients who were within 2-week antipsychotics initial stabilization, and 41 age- and sex-matched healthy controls were enrolled in the study. Group differences in subcortical brain regional structures measured by MRI and the subclinical cardiovascular, metabolic, immune, and neuroendocrine biomarkers as indexed by allostatic load, and their associations were explored. Compared with controls, patients with schizophrenia had significantly higher allostatic load (P = .001). Lateral ventricle (P < .001), choroid plexus (P < .001), and thalamus volumes (P < .001) were significantly larger, whereas amygdala volume (P = .001) was significantly smaller in patients. The choroid plexus alone was significantly correlated with higher allostatic load after age, sex, education level, and the total intracranial volume were taken into account (t = 3.60, P < .001). Allostatic load was also significantly correlated with PANSS positive (r = 0.28, P = .016) and negative (r = −0.31, P = .008) symptoms, but in opposite directions. The peripheral multisystemic and central nervous system abnormalities in schizophrenia may interact through the choroid plexus during the early stage of the illness. The choroid plexus might provide a sensitive structural biomarker to study the treatment and prevention of brain-periphery interaction abnormalities in schizophrenia.
科研通智能强力驱动
Strongly Powered by AbleSci AI