Two Successful Deliveries after 6 and 13 Years from 10 Oocytes Vitrified for Fertility Preservation in a Then 20-Year-Old Patient with PH-Positive Acute Lymphoid Leukemia

Oocyte vitrification is one of the methods for preserving fertility of cancer patients. In 2013, we reported a successful live birth using cryopreserved oocytes from a patient who contracted Ph-positive acute lymphoid leukemia at the retrieval age of 20. In this report, we described a second live birth from the same patient. The patient visited our clinic in November 2018 hoping to utilize vitrified oocytes cryopreserved in 2007. As a result, a day 3 single eight-cell stage embryo was transferred in a hormone replacement therapy cycle. She became pregnant and gave birth to a healthy girl (2,740 g) in September 2019. This is a case report of two live births from 10 matured oocytes that had been preserved for 12 years.