阿尔法(金融)
α粒子
线性能量转移
靶向治疗
细胞毒性T细胞
癌症研究
放射治疗
人口
医学
DNA损伤
癌症治疗
癌症
核医学
化学
内科学
物理
DNA
外科
体外
辐射
核物理学
环境卫生
生物化学
患者满意度
结构效度
作者
Martina Sollini,Katia Marzo,Arturo Chiti,Margarita Kirienko
出处
期刊:Rendiconti lincei. Scienze fisiche e naturali
日期:2020-05-09
卷期号:31 (2): 231-247
被引量:12
标识
DOI:10.1007/s12210-020-00900-2
摘要
Cancer is the second cause of death and morbidity in Europe. Unfortunately, currently available treatments cannot permanently cure most cancers, especially when metastatic. New therapy approaches are, therefore, urgently needed. Radionuclide therapy deposits cytotoxic radiation by means of energetic particles (alfa, beta, and auger) labeled to a carrier that specifically targets cancer cells. Targeted Alpha Therapy is very promising, because alpha particles deliver high energy (i.e., cytotoxic effect) in a small range, binding a target cell population without significant harm to healthy tissues. The high linear energy transfer typical of alpha particles determines irreversible double-strand DNA breaks with per-unit absorbed doses of acute biologic effects three-to-seven times greater than the damage produced by external beam with photons or beta radiation. As consequence, cells—not equipped to efficiently repair this type of damage—typically undergo death. Therefore, Targeted Alpha Therapy is such a new approach to treat tumors. This article aimed to provide an overview (five “W”s and “How”) on Targeted Alpha Therapy.
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