[The calcium and phosphorus content of the bone tissue in ovariectomized rats with a fracture of the tibia: the effect of vitamin K and vitamin D metabolites].

Calcium and phosphorus content in the bone tissue of ovariectomized rats with a shinbone fracture has been estimated. It was found out that unlike pseudo-operated animals whose fracture was accompanied by a decrease of calcium and phosphorus content and density in the right proximal epiphysis of the femur, in case of ovariectomized rats those parameters increased. Under those conditions a decrease in the epiphysis density and calcium and phosphorus content both in the shinbone and in the femur of the left extremity was similar both in pseudo-operated and ovariectomized rats. Administration of 1 alpha (OH)D3, 24R, 25(OH)2D3 and vitamin K to ovariectomized animals with a shinbone fracture produced no positive effect on the bone tissue, which anyhow, did not exclude a possibility of a positive effect in other doses and for a longer period of time.