The Protection of Huoxue Grainula to Ischemical Reperfusion Injury of Rat's Limb

Objective:To evaluate the changes of microcirculation on ischemia reperfusion injury of extremities and the pyotective effects of Huoxue grainula.Methods:40 wister mice were devided into two groups.Huoxue pellet was applicated in experimental group instead of saline in control group after ischemia and reperfusion.The changes of microcirculation were observed.Results:After 4 hours ischemia and 2 hours reperfusion of limb in control group:blood flow slowed down.Serious no-flow phenomenon,erythrocyte aggragation,large amounts of neutrophil-endothelial adhesion and white microthrombosts were observed in microcirculation.in experimental group:Microcirculation disturbances were alleviated.Conclusion:Huoxuepellet could alleviate ischemia reperfusion injury of extremities by improving microcirculation.