Effects of Qiyue hypolipidemic tablets on blood lipid metabolism in hyperlipidemia rats

Objective To study the effects of Qiyue hypolipidemic tablets (QHT) on blood lipid metabolism in hyperlipidemia rats. Methods Wistar rats were divided into 6 groups at random: normal contrast group, hyperlipidemic model group, positive contrast group and QHT 7.0, 3.5, 1.75 g·kg~-1 groups. These rats were continuously fed for four weeks. So the preventive effects of QHT on experimental hyperlipidemic rats could be observed. After the rats were fed with high-fat feed for one week, they were treated with 7.0,3.5, and 1.75 g·kg~-1 doses of QHT for three weeks. The therapeutical effects of QHT on experimental hyperlipidemia in rats were observed. Results Every dose of QHT could decrease the serum TG, TC, LDL-C , TC/HDL-C and LDL-C/HDL-C and AI in hyperlipidemic rats. And the theraputical dose of QHT increased the serum HDL-C in experimental hyperlipidemic rat model. Conclusion QHT have preventive and therapeutical effects in experimental hyperlipidemia rats.