吉非罗齐
洛伐他汀
医学
横纹肌溶解症
肌病
相伴的
肌红蛋白尿
肌酸激酶
内科学
他汀类
药理学
胃肠病学
胆固醇
作者
L. Ross Pierce,Diane K. Wysowski,Thomas P. Gross
出处
期刊:JAMA
[American Medical Association]
日期:1990-07-04
卷期号:264 (1): 71-71
被引量:365
标识
DOI:10.1001/jama.1990.03450010075034
摘要
The Food and Drug Administration documents the receipt of 12 case reports of severe myopathy or rhabdomyolysis associated with concomitant use of lovastatin and gemfibrozil, including 10 voluntary postmarketing, and 2 required, reports. All patients had serum creatine kinase levels of more than 10,000 U/L, 4 tested showed myoglobinuria, and 5 had acute renal failure. The patients' symptoms resolved when both drugs were discontinued. For the first year of marketing of lovastatin, spontaneous reports of myopathy with documentation of creatine kinase level were reviewed for the use of lovastatin, gemfibrozil, and combination therapy. The median creatine kinase level in reports involving concomitant lovastatin and gemfibrozil use was 15,250 U/L, 20 times that in reports with gemfibrozil use alone and 30 times that in reports with lovastatin use alone. Because of the potential for severe myopathy and life-threatening rhabdomyolysis, and given alternative drug combinations for treating hyperlipoproteinemia, the use of lovastatin in combination with gemfibrozil is to be discouraged.
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