Glucose detection through surface-enhanced Raman spectroscopy: A review

Glucose detection is of vital importance to diabetes diagnosis and treatment. Optical approaches in glucose sensing have received much attention in recent years due to the relatively low cost, portable, and mini-invasive or non-invasive potentials. Surface enhanced Raman spectroscopy (SERS) endows the benefits of extremely high sensitivity because of enhanced signals and specificity due to the fingerprint of molecules of interest. However, the direct detection of glucose through SERS was challenging because of poor adsorption of glucose on bare metals and low cross section of glucose. In order to address these challenges, several approaches were proposed and utilized for glucose detection through SERS. This review article mainly focuses on the development of surface enhanced Raman scattering based glucose sensors in recent 10 years. The sensing mechanisms, rational design and sensing properties to glucose are reviewed. Two strategies are summarized as intrinsic sensing and extrinsic sensing. Four general categories for glucose sensing through SERS are discussed including SERS active platform, partition layer functionalized surface, boronic acid based sensors, and enzymatic reaction based biosensors. Finally, the challenges and outlook for SERS based glucose sensors are also presented.