酞菁
安培法
循环伏安法
菲咯啉
检出限
共价有机骨架
铜
纳米颗粒
席夫碱
氧化剂
生物相容性
材料科学
化学
核化学
无机化学
电化学
共价键
纳米技术
高分子化学
有机化学
电极
物理化学
色谱法
作者
Minghua Wang,Lei Zhu,Shuai Zhang,Yafei Lou,Shuangrun Zhao,Quan Tan,Linghao He,Miao Du
标识
DOI:10.1016/j.snb.2021.129826
摘要
A novel metallo-copper phthalocyanine-based covalent-organic framework (CuTAPc-MCOF) doped with silver nanoparticles (denoted as [email protected]) was developed. CuTAPc-MCOF was synthesized using Cu(II) 4′,4′′,4′′′,4′′′′-tetra-amine phthalocyanine (CuTAPc) and 2,9-bis[p-(formyl)phenyl]-1,10-phenanthroline as building blocks through the Schiff base condensation reaction. The basic characterizations revealed that CuTAPc-MCOF demonstrated extended π-system and possessed the phenanthroline group, which can be coordinated with Ag. Consequently, it endowed the [email protected] nanohybrid with good biological compatibility, boosted electron transfer, and produced abundant catalytic active sites. As such, the [email protected] nanohybrid illustrated superior biocompatibility and excellent electrocatalytic activity, thereby showing remarkable electrocatalytic performance for electro-oxidizing nitric oxide (NO) released from living cancer cells. The sensing properties of the [email protected] sensor were measured by cyclic voltammetry and amperometry techniques. The [email protected] electrochemical sensor showed a high sensitivity of 29.1 μA μM−1 cm−2 and a low detection limit of 12.6 nM within the concentration range of 0.18 μM to 17.1 μM toward NO, together with excellent selectivity, high reproducibility and repeatability, and good stability. Overall, our sensing strategy showed potential application in detecting NO released from living cancer cells and diagnosing biological processes.
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