脂肪因子
内科学
瘦素
内分泌学
生长素
糖尿病
医学
胆固醇
激素
肥胖
作者
Munevver Gizem Hekim,Muhammed Mirac Keleştemur,Funda Gülcü Bulmuş,Batuhan Bilgin,Ferah Bulut,Ebru Gokdere,Mehmet Ridvan Ozdede,Haluk Keleştimur,Sinan Canpolat,Mete Özcan
标识
DOI:10.1080/13813455.2021.1894178
摘要
We aimed to investigate the effects of asprosin on diabetes with a focus on serum glucose, irisin, ghrelin, leptin levels and hepatic levels of triglycerides (TG), cholesterol, low-density lipoprotein (LDL).Asprosin (10 µg/kg) was administered intraperitoneally four times at 3-day intervals and then blood and hepatic parameters above mentioned were investigated in control and diabetic mice.The administration of asprosin increased blood glucose level in healthy animals (p = .05) whereas it did not change blood glucose level in diabetic animals. In addition, while asprosin decreased irisin level and increased ghrelin level, it did not change leptin level in diabetic mice. Therewithal, asprosin decreased the increasing levels in hepatic TG, cholesterol, and LDL in diabetic mice.Our novel findings implicate that asprosin may be a target molecule in preventing the development and complications of diabetes.
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