化学
碳二亚胺
基质(水族馆)
组合化学
范围(计算机科学)
组分(热力学)
偶联反应
有机化学
药物化学
立体化学
催化作用
热力学
地质学
物理
海洋学
程序设计语言
计算机科学
作者
Debashish Mishra,Prodeep Phukan
标识
DOI:10.1021/acs.joc.1c01578
摘要
A unified approach has been developed for the synthesis of both isourea and isothiourea in a three-component coupling reaction by treating alcohols or thiols respectively with N,N-dibromoarylsulfonamides and isonitrile and in the presence of K2CO3. This metal-free process proceeds via carbodiimide intermediate at room temperature within a very short reaction time. A library of sulfonylisoureas and isothioureas has been made using this synthetic protocol with wide substrate scope in good to high yields.
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