A palladium/Et3N·HI-catalyzed highly selective 7-endo alkyl-Heck-type reaction of epoxides and a DFT study on the mechanism

A highly efficient 7- endo alkyl-Heck reaction was achieved via palladium catalyzed ring-opening of epoxides, providing a variety of 6-aryl-2,3,4,7-tetrahydro-1 H -azepin-3-ols and 6-aryl-2,3,4,5-tetrahydrooxepin-3-ols.