Rhodium(I)‐Catalyzed Intermolecular Hydroacylation of α‐Keto Amides and Isatins with Non‐Chelating Aldehydes

Abstract The application of the bidentate, electron‐rich bisphosphine ligand, 1,3‐bis(dicyclohexyl)phosphine‐propane (dcpp), in rhodium(I)‐catalyzed intermolecular ketone hydroacylation is herein described. Isatins and α‐keto amides are shown to undergo hydroacylation with a variety of non‐chelating linear and branched aliphatic aldehydes. Also reported is the synthesis of new bidentate chiral phosphine ligands, and their application in hydroacylation is discussed. magnified image