Development of a High-Throughput Experimentation Workflow for Photochemical Reaction Screening

Commercially available lab equipment was successfully integrated to enable visible-range photochemistry in a high-throughput 96-well screening format with magnetic stirring. Precise temperature control with maximal throughput was achieved by positioning the light source above the reaction mixtures and a cooling source below. This platform was benchmarked against other state-of-the-art commercial options using the Doyle-MacMillan reaction. Establishing a highly irradiated, temperature-controlled micromole-scale high-throughput experimentation (HTE) reaction screening protocol in a standard 96-well format could potentially accelerate modern reaction optimization in both medicinal and process chemistry.