Harnessing X-ray-Induced NIR-II Afterglow through ROS-Mediated Molecular Activation for Tumor Radiotheranostics

) adds to the adamantylidene unit, and the resulting chemiexcitation transfers the released energy to the rhodamine perchlorate acceptor to produce an NIR-II afterglow. Meanwhile, the probe enables sustained singlet-oxygen production, synergistically enhancing tumor cell eradication while reducing the required radiation dose. This integrated molecular design establishes a unified platform for NIR-II afterglow-guided radiotheranostics, demonstrating the potential of rational molecular engineering to address the limitations of conventional X-ray-responsive agents and achieve spatiotemporally controlled cancer diagnosis and treatment.