试剂
镍
烷基
烷基化
硼
化学
催化作用
配体(生物化学)
对映选择合成
分子
组合化学
立体化学
有机化学
生物化学
受体
作者
Jens Schmidt,Jun Won Choi,Albert Tianxiang Liu,Martin Slusarczyk,Gregory C. Fu
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2016-12-09
卷期号:354 (6317): 1265-1269
被引量:197
标识
DOI:10.1126/science.aai8611
摘要
Crafting chiral boron building blocks Carbon-boron bonds are easily transformed into a wide variety of C–C, C–N, and C–O bonds. With that flexibility in mind, Schmidt et al. show that nickel complexes can catalyze asymmetric alkylation of carbon centers adjacent to boron. This protocol creates chiral alkylboronates that function as stable precursors to numerous complex molecules. The reaction proceeds in stereo-convergent fashion—forming a single product from either mirror image of the α-haloboronate reagent. Successive reactions can also create chains of adjacent chiral alkyl centers with stereochemistry set by the configuration of the ligand bound to nickel. Science , this issue p. 1265
科研通智能强力驱动
Strongly Powered by AbleSci AI