Visible-Light Mediated, Dual-Catalysis Enabled Allylic Difluoroalkylation via Halogen Atom Transfer

A visible-light-mediated protocol employing a halogen atom transfer strategy (XAT) has been developed for the synthesis of homoallylic difluorinated compounds. Employing a dual-catalysis reactivity manifold, which includes a cobaloxime catalyst, the reaction occurs without exogenous oxidant and under mild conditions. The applicability of unactivated olefins, a wide variety of halogenated precursors, and access to a diverse family of difluoromethylated molecular architectures are the highlights of this method.