适体
核酸
核酸酶
化学
结合亲和力
计算生物学
小分子
临床诊断
纳米技术
组合化学
DNA
生物化学
生物
重症监护医学
分子生物学
医学
材料科学
受体
作者
Malaya Mili,Vinay Bachu,Pooja Rani Kuri,Naveen K. Singh,Pranab Goswami
标识
DOI:10.1016/j.bpc.2024.107218
摘要
Nucleic acid aptamers have captivated the attention of analytical and medicinal scientists globally due to their several advantages as recognition molecules over conventional antibodies because of their small size, simple and inexpensive synthesis, broad target range, and high stability in varied environmental conditions. These recognition molecules can be chemically modified to make them resistant to nuclease action in blood serum, reduce rapid renel clearance, improve the target affinity and selectivity, and make them amenable to chemically conjugate with a support system that facilitates their selective applications. This review focuses on the development of efficient aptamer candidates and their application in clinical diagnosis and therapeutic applications. Significant advances have been made in aptamer-based diagnosis of infectious and non-infectious diseases. Collaterally, the progress made in therapeutic applications of aptamers is encouraging, as evident from their use in diagnosing cancer, neurodegenerative diseases, microbial infection, and in imaging. This review also updates the progress on clinical trials of many aptamer-based products of commercial interests. The key development and critical issues on the subject have been summarized in the concluding remarks.
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