微泡
纳米载体
细胞外小泡
胞外囊泡
药物输送
生物
细胞外
药品
核酸
细胞生物学
免疫系统
计算生物学
炎症
氧化应激
纳米技术
药理学
生物化学
小RNA
免疫学
材料科学
基因
作者
Mingyue Shao,Xiao Jin,Sixi Chen,Ning Yang,Ganzhu Feng
标识
DOI:10.1016/j.biopha.2023.115904
摘要
Plant-derived extracellular vesicles (PDEVs) have shown remarkable potential as sustainable, green, and efficient drug delivery nanocarriers. As natural nanoparticles containing lipids, protein, nucleic acids and secondary metabolites, they have received widespread attention as a replacement for mammalian exosomes in recent years. In this review, the advances in isolation, identification, composition, therapeutic effect, and clinical application prospect were comprehensively reviewed, respectively. In addition, the specific modification strategies have been listed focusing on the inherent drawbacks of the raw PDEVs like low targeting efficiency and poor homogeneity. With emphasis on their biology mechanism in terms of immune regulation, regulating oxidative stress and promoting regeneration in the anti-inflammatory field and application value demonstrated by citing some typical examples, this review about PDEVs would provide a broad and fundamental vision for the in-depth exploration and development of plant-derived extracellular vesicles in the in-vivo anti-inflammation and even other biomedical applications.
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