This article discusses the clinical features of Kawasaki disease in children with concurrent liver dysfunction and analyzes possible causes. Forty cases of Kawasaki disease in children with liver dysfunction and 36 cases of Kawasaki disease in children without liver dysfunction from a certain hospital between 2021 and 2022 were selected as the research subjects. Liver function indicators, electrocardiographic indicators, and treatment strategies were compared between the two groups of children. The study found that children with Kawasaki disease and concurrent liver dysfunction had significantly higher levels of ALT, AST, and TBIL, and significantly lower levels of ALB. The study suggests that children with Kawasaki disease and concurrent liver dysfunction have clinical features of elevated levels of ALT, AST, and TBIL, and the main treatment methods are immunoglobulin and hepatoprotective drugs. The etiology of this condition may be related to liver cell damage caused by immune reactions and oxidative stress, among other factors.