化学
共价键
标签
降级（电信）
立体化学
组合化学
生物化学
有机化学
电信
计算机科学
作者
Muhammad Murtaza Hassan,Yen-Der Li,W Michelle,Mingxing Teng,Woong Sub Byun,Kedar Puvar,Ryan J. Lumpkin,Brittany Sandoval,Justine C. Rutter,Cyrus Y Jin,Michelle Wang,Shawn Xu,Anna M. Schmoker,Hakyung Cheong,Brian J. Groendyke,Jun Qi,Eric S. Fischer,Benjamin L. Ebert,Nathanael S. Gray
标识
DOI：10.1016/j.ejmech.2024.116904
摘要
Chemically induced proximity modalities such as targeted protein degradation (TPD) hold promise for expanding the number of proteins that can be manipulated pharmacologically. However, current TPD strategies are often limited to proteins with preexisting ligands. Molecular glues (e.g. glutarimide ligands for CUL4
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