Genetic Small-Vessel Diseases

Brain infarction due to cerebral small vessel disease (SVD) accounts for up to 25% of all ischemic strokes. CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) and CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) are among the monogenic hereditary cerebral SVDs. Herein, we reported a case of sporadic CADASIL-like disease and provided information about CADASIL and CARASIL, two of the most common of inheredited SVDs that are usually overlooked