Novel Cyclic Peptides Inhibiting Tumor Necrosis Factor Receptor 1 Activity

This patent application pertains to macrocyclic peptides, generally represented by Formula I. These compounds exhibit selective binding to tumor necrosis factor receptor 1 (TNFR1) and hold the potential for mitigating the progression of diseases or disorders associated with TNFα/TNFR1 signaling, including autoimmune and inflammatory conditions.