Rhodium(III)-Catalyzed C–C Bond Formation by Direct C–H Activation

Abstract Transition-metal-catalyzed functionalizations of C–H bonds to construct C–C bonds represent an ideal route in the synthesis of valuable organic molecules. In particular, rhodium(III)-catalyzed C–H bond activation offers an attractive strategy due to its efficiency and step economy for direct functionalization in organic synthesis. Consequently, recent developments in this area have assured a high level of regioselectivity in C–H functionalization reactions. In this Account, we have summarized our recent achievements in the functionalizations of sp2- and sp3-C–H bonds using rhodium catalyst. The scope, limitation, and mechanism of these reactions have been described briefly. 1 Introduction 2 C–H Arylation 2.1 Aromatic C(sp2)–H Arylation 2.2 Benzylic C(sp3)–H Arylation 2.3 Olefinic C(sp2)–H Arylation 3 Olefinic C(sp2)–H Alkenylation and Alkylation 4 Olefinic C(sp2)–H Heteroarylation 5 Conclusion