Tuning of a Hydrogen‐Bonded Organic Framework by Liquid‐Assisted Mechanosynthesis between Trans‐Aconitic Acid and Isonicotinamide

has been determined by Single Crystal X-ray diffraction (SCXRD), crystal structures of 3 cocrystal HOFs were determined by microcrystal electron diffraction (MicroED) and synchrotron X-ray diffraction due to lack of suitable single crystal. PXRD analysis confirms isostructurality of various host-guest systems; whereas guest incorporation as well as stability of the HOFs were further confirmed using thermogravimetric analysis. This study demonstrates that the framework of HOFs can be tuned by varying solvent molecules used during LAG.