Repeated bout effect of exercise on cardiac troponin release is lost in individuals with cardiovascular disease: a cause for concern?

Editorial FocusExercise, Physical Activity, and Cardiovascular HealthRepeated bout effect of exercise on cardiac troponin release is lost in individuals with cardiovascular disease: a cause for concern?Brady J. HolmerBrady J. HolmerDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, United StatesPublished Online:31 Mar 2023https://doi.org/10.1152/ajpheart.00114.2023This is the final version - click for previous versionMoreSectionsFull TextPDF (197 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations "Repeated bout effect of exercise on cardiac troponin release is lost in individuals with cardiovascular disease: a cause for concern?." American Journal of Physiology-Heart and Circulatory Physiology, 324(5), pp. H633–H634REFERENCES1. Thompson PD, Buchner D, Pina IL, Balady GJ, Williams MA, Marcus BH, Berra K, Blair SN, Costa F, Franklin B, Fletcher GF, Gordon NF, Pate RR, Rodriguez BL, Yancey AK, Wenger NK; American Heart Association Council on Clinical Cardiology Subcommittee on Exercise, Rehabilitation, and Prevention; American Heart Association Council on Nutrition, Physical Activity, and Metabolism Subcommittee on Physical Activity. Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity). Circulation 107: 3109–3116, 2003. doi:10.1161/01.CIR.0000075572.40158.77.Crossref | PubMed | ISI | Google Scholar2. Shave R, Baggish A, George K, Wood M, Scharhag J, Whyte G, Gaze D, Thompson PD. Exercise-induced cardiac troponin elevation: evidence, mechanisms, and implications. J Am Coll Cardiol 56: 169–176, 2010. doi:10.1016/j.jacc.2010.03.037.Crossref | PubMed | ISI | Google Scholar3. Canty JM Jr. Myocardial injury, troponin release, and cardiomyocyte death in brief ischemia, failure, and ventricular remodeling. Am J Physiol Heart Circ Physiol 323: H1–H15, 2022. doi:10.1152/ajpheart.00093.2022.Link | ISI | Google Scholar4. Eijsvogels TMH, Hoogerwerf MD, Oudegeest-Sander MH, Hopman MTE, Thijssen DHJ. The impact of exercise intensity on cardiac troponin I release. Int J Cardiol 171: e3–e4, 2014. doi:10.1016/j.ijcard.2013.11.050.Crossref | PubMed | ISI | Google Scholar5. Thijssen DHJ, Uthman L, Somani Y, van Royen N. Short-term exercise-induced protection of cardiovascular function and health: why and how fast does the heart benefit from exercise? J Physiol 600: 1339–1355, 2022. doi:10.1113/JP282000.Crossref | PubMed | Google Scholar6. Seeger JPH, Benda NMM, Riksen NP, van Dijk APJ, Bellersen L, Hopman MTE, Cable NT, Thijssen DHJ. Heart failure is associated with exaggerated endothelial ischaemia-reperfusion injury and attenuated effect of ischaemic preconditioning. Eur J Prev Cardiol 23: 33–40, 2016. doi:10.1177/2047487314558377.Crossref | PubMed | ISI | Google Scholar7. Somani YB, Uthman L, Aengevaeren VL, Rodwell L, Lip GYH, Hopman MTE, Van Royen N, Eijsvogels TMH, Thijssen DHJ. Exercise-induced release of cardiac troponin is attenuated with repeated bouts of exercise: impact of cardiovascular disease and risk factors. Am J Physiol Heart Circ Physiol 324: H519–H524, 2023. doi:10.1152/ajpheart.00033.2023.Link | Google Scholar8. Aengevaeren VL, Hopman MTE, Thompson PD, Bakker EA, George KP, Thijssen DHJ, Eijsvogels TMH. Exercise-induced cardiac troponin I increase and incident mortality and cardiovascular events. Circulation 140: 804–814, 2019. doi:10.1161/CIRCULATIONAHA.119.041627.Crossref | PubMed | ISI | Google Scholar9. Mehta R, Gaze D, Mohan S, Williams KL, Sprung V, George K, Jeffries R, Hudson Z, Perry M, Shave R. Post-exercise cardiac troponin release is related to exercise training history. Int J Sports Med 33: 333–337, 2012. doi:10.1055/s-0031-1301322.Crossref | PubMed | ISI | Google Scholar10. Balmain BN, Sabapathy S, Yamada A, Shiino K, Chan J, Haseler LJ, Kavanagh JJ, Morris NR, Stewart GM. Cardiac perturbations after high-intensity exercise are attenuated in middle-aged compared with young endurance athletes: diminished stress or depleted stimuli? Am J Physiol Heart Circ Physiol 320: H159–H168, 2021. doi:10.1152/ajpheart.00427.2020.Link | ISI | Google Scholar Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation CollectionsAJP-Heart CollectionsExercise, Physical Activity, and Cardiovascular HealthThis collection focuses on the key physiological relationships between exercise, physical activity, and cardiovascular health in both animal and human models. Related ArticlesExercise-induced release of cardiac troponin is attenuated with repeated bouts of exercise: impact of cardiovascular disease and risk factors 20 Mar 2023American Journal of Physiology-Heart and Circulatory Physiology More from this issue > Volume 324Issue 5May 2023Pages H633-H634 Crossmark Copyright & PermissionsCopyright © 2023 the American Physiological Society.https://doi.org/10.1152/ajpheart.00114.2023PubMed36897747History Received 27 February 2023 Accepted 9 March 2023 Published online 31 March 2023 Published in print 1 May 2023 Keywordsaerobic exercisecardiac troponincardiovascular diseaseexerciseexercise-induced cardioprotection Metrics