封锁
免疫系统
免疫检查点
抗原呈递
免疫学
人类白细胞抗原
T细胞
抗原
渲染(计算机图形)
生物
医学
免疫疗法
癌症研究
计算机科学
内科学
受体
计算机图形学(图像)
作者
Hui‐Fern Koay,Lydia Lynch
标识
DOI:10.1016/j.it.2023.01.011
摘要
Tumors can evade conventional T cell recognition by rendering the HLA class I antigen presentation system defective. In a recent study, de Vries et al. reveal γδ T cells as key contributors to the efficacy of immune checkpoint blockade (ICB) against HLA-I-silenced cancers, highlighting a novel layer of surveillance against immune escape by tumors.
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