脂质体
部分
药物输送
聚合物
材料科学
纳米技术
毒品携带者
组合化学
化学
有机化学
作者
Javesh Patil,Tejasweeni Girase,Sulbha G. Patil,Hemant Suryawanshi,Sunila A. Patil
标识
DOI:10.3390/ecsoc-26-13640
摘要
Liposomes are artificial vesicles encapsulating the drug moiety. The structural adaptability of liposomes has been employed to make them drug carriers for smart delivery systems, improving bioavailability, stability, target delivery, etc. However, conventional liposomes have some drawbacks, such as limited payload, shorter in vivo circulatory lifespan, unregulated releasing properties, rapid clearance from bloodstream, etc. Polymeric modification of the liposomes addressed and effectively overcame all the drawbacks of conventional liposomes. Polymeric materials offer indefinite structural diversity, thus a substantial portion of the materials has been employed for drug-targeting methods and controlled drug release. Conjugation of liposomes and polymers develops a hybrid vesicle with intermediary physicochemical and stimulus responsive properties (pH, temperature, etc.). The reliability of liposomes with respect to pH, nature of drug moiety, enzyme, and immune response can be strengthened by polymers. Polymer modified liposomes also enhance the pharmacokinetic and pharmacodynamic profile of the drug moiety. The form of polymer, cross-linking agent, interaction, and bonding used during polymerized modification of liposomes all have an impact on their activity. According to the extensive review of the literature that is accessible in the different data sources, research in this field is proactively involved in the synthesis of newer polymeric materials, and the supramolecular structuring of the different chemicals.
科研通智能强力驱动
Strongly Powered by AbleSci AI