Intra-class consistency and inter-class discrimination feature learning for automatic skin lesion classification

Automated skin lesion classification has been proved to be capable of improving the diagnostic performance for dermoscopic images. Although many successes have been achieved, accurate classification remains challenging due to the significant intra-class variation and inter-class similarity. In this article, a deep learning method is proposed to increase the intra-class consistency as well as the inter-class discrimination of learned features in the automatic skin lesion classification. To enhance the inter-class discriminative feature learning, a CAM-based (class activation mapping) global-lesion localization module is proposed by optimizing the distance of CAMs for the same dermoscopic image generated by different skin lesion tasks. Then, a global features guided intra-class similarity learning module is proposed to generate the class center according to the deep features of all samples in one class and the history feature of one sample during the learning process. In this way, the performance can be improved with the collaboration of CAM-based inter-class feature discriminating and global features guided intra-class feature concentrating. To evaluate the effectiveness of the proposed method, extensive experiments are conducted on the ISIC-2017 and ISIC-2018 datasets. Experimental results with different backbones have demonstrated that the proposed method has good generalizability and can adaptively focus on more discriminative regions of the skin lesion.