NHPI/O2‐Mediated Electrochemical Intermolecular Cyclization/Dehydrogenation for the Construction of Polycyclic Quinazolinones

Abstract Herein, an eco‐friendly and atom‐economical electrochemical methodology with isatins and 1,2,3,4‐tetrahydroisoquinolines through NHPI/O 2 ‐mediated intermolecular oxidation/annulation is disclosed, leading to a variety of polycyclic quinazolinones in 46–82% yields. This oxidative cyclization proceeded in transition metal‐ and strong oxidant‐free conditions and generated H 2 and CO 2 as byproducts. Additionally, late‐stage functionalization and broad substrate scope demonstrated the synthetic usefulness of this protocol.