IDH2型
胶质瘤
IDH1
遗传学
突变体
生物
癌症研究
基因
作者
Ingo K. Mellinghoff,Martin J. van den Bent,Deborah T. Blumenthal,Mehdi Touat,Katherine B. Peters,Jennifer Clarke,Joe Mendez,Shlomit Yust‐Katz,Liam Welsh,Warren Mason,François Ducray,Yoshie Umemura,Burt Nabors,Matthias Holdhoff,Andreas F. Hottinger,Yoshiki Arakawa,Juan Manuel Sepúlveda-Sánchez,Wolfgang Wick,Riccardo Soffietti,James Perry
标识
DOI：10.1056/nejmoa2304194
摘要
Isocitrate dehydrogenase (IDH)-mutant grade 2 gliomas are malignant brain tumors that cause considerable disability and premature death. Vorasidenib, an oral brain-penetrant inhibitor of mutant IDH1 and IDH2 enzymes, showed preliminary activity in IDH-mutant gliomas.
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