医学
哮喘
肺活量
胎龄
出生体重
人口
肺功能测试
肺容积
儿科
肺
内科学
肺功能
怀孕
扩散能力
环境卫生
生物
遗传学
作者
Hwan Soo Kim,Seung Won Lee,Jin Tack Kim,Jung Hoon Kim,Dae Hyun Lim,Woo Kyung Kim,Dae Jin Song,Young Yoo,Dong In Suh,Heysung Baek,Meeyong Shin,Ji Won Kwon,Gwang Cheon Jang,Hyeon‐Jong Yang,Eun Lee,Ju Hee Seo,Sung Il Woo,Hyung Young Kim,Youn Ho Shin,Ju Suk Lee,Sungsu Jung,Nang Kyeong Lee,Jinho Yu
出处
期刊:Respirology
[Wiley]
日期:2023-06-12
卷期号:28 (9): 841-850
被引量:1
摘要
Abstract Background and Objective Preterm birth or fetal growth has been associated with reduced lung function and asthma during childhood in the general population. We aimed to elucidate whether prematurity or fetal growth has a significant influence on lung function or symptoms in children with stable asthma. Methods We included children with stable asthma who participated in the Korean childhood Asthma Study cohort. Asthma symptoms were determined by asthma control test (ACT). Percent predicted values of pre‐ and post‐bronchodilator (BD) lung function including forced expiratory volume in 1 second (FEV 1 ), forced vital capacity (FVC), and forced expiratory flow at 25%–75% of FVC (FEF 25%–75% ) were measured. Lung function and symptoms were compared according to the history of preterm birth and birth weight (BW) for gestational age (GA). Results The study population consisted of 566 children (age range: 5–18 years). There were no significant differences in lung function and ACT between preterm and term subjects. We observed no significant difference in ACT but significant differences were observed in pre‐ and post‐BD FEV 1 , pre‐ and post‐BD FVC, and post‐BD FEF 25%–75% according to BW for GA in total subjects. Two‐way ANOVA revealed that BW for GA rather than prematurity was a significant determining factor for pre‐ and post‐BD lung function. After regression analysis, BW for GA was still a significant determining factor of pre‐ and post‐BD FEV 1 and pre‐ and post‐BD FEF 25%–75% . Conclusion Fetal growth rather than prematurity appears to have a significant effect on lung function in children with stable asthma.
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