子宫内膜
间质细胞
血管生成
血管内皮生长因子
免疫组织化学
川地34
雌激素
医学
生物
男科
内科学
内分泌学
病理
血管内皮生长因子受体
干细胞
遗传学
作者
Michael D. Mueller,Dan I. Lebovic,Evelyn N. Garrett,Robert N. Taylor
标识
DOI:10.1016/s0015-0282(00)00555-0
摘要
To identify leukocytes within the human endometrium expressing vascular endothelial growth factor (VEGF).Prospective cohort study.Healthy volunteers in an academic research environment.Twenty-one normal cycling women without abnormal menstrual bleeding or infertility.Endometrial tissue collection by Pipelle de Cornier aspiration.Histologic, immunohistochemical (CD3, CD34, CD56, CD68, neutrophil elastase, estrogen and P receptors, VEGF), and simultaneous double immunoenzymatic labeling analysis of VEGF-positive cells within the human endometrium.Ten endometrial samples were obtained in the proliferative (cycle days 5-10) and 11 samples in the secretory phase (cycle days 15-26). Immunohistochemical analyses showed the expected distribution of the different leukocyte cell types. Besides epithelial and stromal endometrial cells, the predominant cells that stained for VEGF were neutrophil granulocytes. Neutrophils were more abundant in the secretory phase but they expressed neither estrogen-a nor P receptors.Neutrophil granulocytes infiltrating the human endometrium express VEGF and regulate cyclical endometrial vascular proliferation. Ovarian steroids indirectly influence neutrophil migration.
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