非酒精性脂肪肝
内科学
医学
体质指数
代谢综合征
甘油三酯
横断面研究
胃肠病学
脂肪肝
血压
逐步回归
内分泌学
人口
疾病
肥胖
病理
胆固醇
环境卫生
作者
Jian He,Weilin Mao,Juanwen Zhang,Xi Jin
出处
期刊:Annals of Nutrition and Metabolism
[S. Karger AG]
日期:2015-01-01
卷期号:67 (2): 69-75
被引量:3
摘要
To assess the association between serum sialic acid (SA) levels and nonalcoholic fatty liver disease (NAFLD) in a Chinese population.A cross-sectional study was performed among 3,898 Chinese who took their annual health examination. Serum SA levels and other clinical and laboratory parameters were measured.A total of 18.11% fulfilled the diagnostic criteria of NAFLD. NAFLD subjects with/without metabolic syndrome (MS) had significantly higher serum SA levels than those without NAFLD. Serum SA levels were significantly and positively correlated with components of MS (body mass index, systolic blood pressure, diastolic blood pressure, triglyceride and fasting plasma glucose) in the NAFLD group. Stepwise logistic regression analysis showed that SA levels were significantly associated with the risk factor for NAFLD. Serum SA levels were negatively correlated with the FIB-4 score, and lower serum SA levels were independent factors predicting advanced fibrosis in subjects with NAFLD.Our results showed a significant association between serum SA levels and NAFLD.
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