材料科学
荧光
猝灭(荧光)
检出限
金属
选择性
组氨酸
结晶学
化学
分析化学(期刊)
物理
氨基酸
量子力学
有机化学
色谱法
催化作用
生物化学
作者
Chengxiang Chu,Rui Huang,Xianfeng Wang,Yulin Deng,Tao Gu,Danqun Huo,Liang Zhang,Daidi Zhong,Changjun Hou
出处
期刊:NANO
[World Scientific]
日期:2021-01-19
卷期号:16 (02): 2150015-2150015
被引量:6
标识
DOI:10.1142/s1793292021500156
摘要
As an important amino acid in the body, L-histidine participates in various physiological processes. Therefore, it is of great necessity to establish a rapid and effective method for L-histidine sensing, especially in blood and urine. In this work, a fluorescence sensor for detection of L-histidine was successfully developed using Cu-MOFs/Fe[Formula: see text] sensor. Cu-MOFs with blue emission served as the identification unit and signal source, and Fe[Formula: see text] played the role of “quencher” in this system. Fe[Formula: see text] induced the fluorescence quenching of Cu-MOFs to form Cu-MOFs/Fe[Formula: see text] sensor due to the effect of photoinduced electron transfer (PET). After the addition of L-histidine, Fe[Formula: see text] was captured by L-histidine to form L-histidine-Fe[Formula: see text] complex, which inhibited the PET effect from Cu-MOFs to Fe[Formula: see text], resulting in the fluorescence recovery of Cu-MOFs. With such a design, L-histidine detection was realized with a wide linear range from 1[Formula: see text][Formula: see text]M to 190[Formula: see text][Formula: see text]M. The limit of detection (LOD) was calculated as low as 0.156[Formula: see text][Formula: see text]M. In addition, successful detection of L-histidine in blood serum with high selectivity and sensitivity indicated the real applications and potential diagnostic value of Cu-MOFs/Fe[Formula: see text] system.
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