光热治疗
线粒体
药物输送
体内
放射治疗
靶向给药
癌细胞
癌症研究
胶质瘤
结合
材料科学
纳米技术
靶向治疗
表面改性
化学
纳米颗粒
生物物理学
癌症
生物化学
生物
医学
物理化学
生物技术
数学分析
内科学
遗传学
数学
作者
Abhijeet Pandey,Kritarth Singh,Suresh Subramanian,Aruna Korde,Rajesh Singh,Krutika Sawant
标识
DOI:10.1016/j.cej.2020.124419
摘要
Inorganic materials have lot of attention owing to their unique properties which can be explored for multiple biomedical application. Recently, alloy nanoparticles have been shown as potential candidate for multimodal therapy and imaging of cancer. In the present study, a novel pH responsive poly-l-lysine coated Fe3O4@FePt core shell nanoparticles have been developed for mitochondria targeted (Mito-PANPs) therapy of glioblastoma. The surface of synthesized nanoparticles was modified with mitochondria directing triphenylphsphonium ion (TPP) and hypoxic cancer cell directing protein chlorotoxin (CTX). An attempt has been made to provide multimodal therapy of GBM by targeting hypoxic tissue in combination with chemotherapeutic agent and chemo-photothermal therapy. The synthesized nanoconjugates were extensively characterized and evaluated. The obtained results demonstrated enhanced localization of mitochondria both in vitro and in vivo. A superior proliferation suppressing ability was observed via multiple molecular mechanism involving disruption in mitochondrial energetics. Considering the mitochondria targeting ability, along with specificity for glioma cells and hypoxic region of glioma, multimodal therapeutic approach (chemotherapy, ROS generation by Fe, photothermal therapy, radiotherapy and DNA strand breakage by Pt) and pH responsive drug release, Mito-PANPs can prove to be a promising nanotheranostic platform for tumor imaging and therapy with externally guided monitoring.
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