GFAP染色
实验性自身免疫性脑脊髓炎
脊髓
胶质纤维酸性蛋白
小胶质细胞
中枢神经系统
炎症
医学
多发性硬化
视神经
星形胶质细胞
免疫学
病理
生物
神经科学
内分泌学
解剖
免疫组织化学
作者
Yinxi Zhang,Yang Zheng,Chun‐Hong Shen,Meiping Ding
出处
期刊:Chin J Neurol
日期:2020-04-08
卷期号:53 (04): 317-320
标识
DOI:10.3760/cma.j.cn113694-20190603-00329
摘要
Autoimmune glial fibrillary acidic protein astrocytopathy is a curable autoimmune inflammatory disease of the central nervous system. Meninges, brain, spinal cord and optic nerve are mainly involved. Radial paraventricular enhancement and/or long segment lesions of spinal cord with central enhancement can be seen on magnetic resonance imaging. Brain biopsy shows perivascular inflammation with microglia activation. The disease is sensitive to steroid therapy. Glial fibrillary acidic protein antibody is considered as a specific biomarker of the disease.
Key words:
Glial fibrillary acidic protein; Oligodendroglia; Inflammation; Hormones
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