生物
表观遗传学
组蛋白
基因表达
转录组
基因表达调控
神经科学
DNA甲基化
N6-甲基腺苷
功能(生物学)
核糖核酸
神经系统
计算生物学
基因
细胞生物学
遗传学
甲基化
甲基转移酶
作者
Ido Livneh,Sharon Moshitch-Moshkovitz,Ninette Amariglio,Gideon Rechavi,Dan Dominissini
标识
DOI:10.1038/s41583-019-0244-z
摘要
The field of epitranscriptomics examines the recently deciphered form of gene expression regulation that is mediated by type- and site-specific RNA modifications. Similarly to the role played by epigenetic mechanisms - which operate via DNA and histone modifications - epitranscriptomic modifications are involved in the control of the delicate gene expression patterns that are needed for the development and activity of the nervous system and are essential for basic and higher brain functions. Here we describe the mechanisms that are involved in the writing, erasing and reading of N6-methyladenosine, the most prevalent internal mRNA modification, and the emerging roles played by N6-methyladenosine in the nervous system.
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