The Result Analysis of Four Kinds of Urine Microprotein in Systemic Lupus Erythematosus

Objective To explore the significance of the urine microalbumin,transferrin,alpha 1-microglobulin,beta 2-microglobulin in SLE patients with early renal damage.Methods One hundred and eight patients with SLE,based on whether had the clinical manifestations of the kidney,were divided into two groups,obvious lupus nephritis group and silent lupus nephritis group,sixty-five healthy donors for normal control group.Immunol scatter turbidity test was used to assay microalbumin,transferrin,alpha 1-microglobulin,beta 2-microglobulin.The automatic biochemistry analyzer(Toshiba 120) was used to assay Serum BUN and Cr.Results The four kinds of microprotein in obvious lupus nephritis group were higher than that in silent lupus nephritis group and the control(P0.05).The four kinds of microprotein in silent lupus nephritis group were higher than those in the control group(P0.05).There were no statistical significance of four performance alone in obvious lupus nephritis group and in silent lupus nephritis group(P0.05).The four kinds of microprotein were jointly tested in Silent Lupus nephritis group.It's found that there was no statistical significance in positive frequency comparing to one index and two indexes,three indexes and four indexes(P 1,2;P3,40.05).However there was statistical difference in comparing one index and three indexes,one index and four indexes,two indexes and three indexes,two indexes and four indexes(P 1,3;P 1,2;P 2,3;P 2,40.05).The result in obvious lupus nephritis group was the same.There was no relationship between urine microalbumin,transferrin,alpha 1-micro globulin,beta 2-micro globulin and serum BUN.There was no statistics correlation between urine transferrin,alpha 1-micro globulin,beta 2-micro globulin and serum creatinine(P0.05).While there was positive relationship between urinary microalbumin and serum creatinine(r=0.737,P0.05).Conclusion The four index united detection can greatly improve the positive rate,indicating the significiance of dynamic monitoring the types and content of urine microprotein to early diagnosis of renal injury in SLE.