The study of the growth behavior of hypertrophic scar fibroblasts versus normal skin fibroblasts

Objective:To study the differences between the growth behavior of hypertrophic scar fibroblasts(HSF) versus normal skin fibroblasts (NSF).Methods:The fibroblasts were established with digesting method.The cell morphology was observed under optic microscope.The cell growth curves were drawn and the growth rates were determined.Results:The hypertrophic scar fibroblasts with more branches protruding from the cell bodies were bigger than the normal skin fibroblasts.The cell double multiplying time of the hypertrophic scar fibroblasts was 6 dyas,much longer than the normal skin fibroblasts.Whereas the ultimate cell number of the former was 56% of the later.Conclusion:The hypertrophic scar fibroblast is a different phenotype from the normal skin fibroblast.