The effect of TGF-beta on the induction CD8 and NK1.1 expression in CTLL-2 cell line.

Our results indicated that these would be useful models to investigate CD8 precursor potentials in populations of CD4-CD8- (double negative) cells and the relationship of NK1.1. These results also support a role for TGF-beta in T-cell differentiation and the hypothesis that T-cells and NK cells may have the same ontogeny.