Overview of human β-defensins in genetic engineering expression

Humanβ-defensins are a kind of polypeptide substances with biological activity produced by human and have a powerful killing effect on bacteria,fungi,viruses,etc.It is expected to become the development of a new class of anti-infective drugs and have a wide application prospect.Genetic engineering technology is the most economic,scientific and effective way to obtain a lot of humanβ-defensins.In this communication,the progress in the structural characteristics,prokaryotic expression and eukaryotic expression systems,and expression technology of humanβ-defensins are reviewed.The results provide reference for their further development and utilization.